GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs11190604 | 1 | rs79831012 | chr10:102237059 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.11 | 4.24E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs12889813 | 1 | rs8003764 | chr14:24304391 | NGDN | chr14:23938898-23947401:+ | 0.67 | 5.25 | 2.56E-6 | Antibody level in response to infection |
| UVM | cis | rs12889813 | 1 | rs8007170 | chr14:24301512 | NGDN | chr14:23938898-23947401:+ | 0.65 | 5 | 6.22E-6 | Antibody level in response to infection |
| UVM | cis | rs2985684 | 1 | rs8014170 | chr14:50071694 | RPL36AL | chr14:50085407-50087349:- | 0.53 | 5.74 | 4.21E-7 | Carotid intima media thickness |
| UVM | cis | rs78153629 | 1 | rs8026523 | chr15:40654066 | C15orf23 | chr15:40674922-40686488:+ | 0.92 | 6.6 | 1.72E-8 | Heschl's gyrus morphology |
| UVM | cis | rs78153629 | 1 | rs8027487 | chr15:40654067 | C15orf23 | chr15:40674922-40686488:+ | 0.92 | 6.6 | 1.72E-8 | Heschl's gyrus morphology |
| UVM | cis | rs2028299 | 1 | rs8031576 | chr15:90380214 | AP3S2 | chr15:90373832-90456222:- | -0.73 | -5.98 | 1.75E-7 | Type 2 diabetes |
| UVM | cis | rs78153629 | 1 | rs8033303 | chr15:40649700 | C15orf23 | chr15:40674922-40686488:+ | 0.88 | 5.8 | 3.36E-7 | Heschl's gyrus morphology |
| UVM | cis | rs78153629 | 1 | rs8033938 | chr15:40703114 | C15orf23 | chr15:40674922-40686488:+ | 0.84 | 5.16 | 3.44E-6 | Heschl's gyrus morphology |
| UVM | cis | rs9902453 | 1 | rs8065059 | chr17:28417376 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -4.98 | 6.54E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9902453 | 1 | rs8065261 | chr17:28418041 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -4.98 | 6.54E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs8078723 | 1 | rs8070454 | chr17:38160754 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -7.55 | 4.73E-10 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs807669 | 1 | rs807669 | chr22:19154522 | SLC25A1 | chr22:19163095-19166301:- | -0.27 | -4.74 | 1.56E-5 | Metabolite levels |
| UVM | cis | rs8078723 | 1 | rs8078723 | chr17:38166879 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -7.55 | 4.73E-10 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs8135828 | 1 | rs8135828 | chr22:29929239 | CABP7 | chr22:30116344-30127818:+ | -1.03 | -6.84 | 6.87E-9 | Lipid traits |